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203 articles
The latest Nature Biotechnology item is not a new experiment but an author correction, yet it touches a paper aimed at one of CRISPR biology’s sharper frontiers: directing Cas12a systems toward RNA targets.
Researchers have used light to push chemistry uphill: the creation of tiny, strained housane molecules.
A new mouse study suggests Alzheimer’s pathology may not have to be attacked only inside neurons, but also through repair of the brain’s cleanup system.
A new mouse study strengthens the idea that sperm carries not just DNA, but RNA signals linked to a father’s preconception experiences.
A uterine-lining organoid lets researchers watch tissue shed and repair without forming scars.
Researchers linked a set of SP genes to regeneration in axolotls, zebrafish and mice, opening an early path to understanding tissue repair.
Researchers linked a set of SP genes to regeneration in axolotls, zebrafish and mice, opening an early path to understanding tissue repair.
Swedish researchers developed a more reliable way to make insulin-producing cells that restored glucose control in mice.
ARTEMIS reached more than 70,000 adolescents in New Delhi and Vijayawada and enrolled 3,739 young people for care evaluation.
A startup claims it created functional human sperm from stem cells and used it to form embryos, but the evidence has not yet been independently published.
Forty-two β-thalassaemia patients in a Milan-led trial stopped needing blood transfusions after CRISPR edited their *BCL11A* gene to boost fetal hemoglobin.
Electrodes in epilepsy patients revealed identical brain activity for seeing and imagining objects.
MD Anderson’s team pinpointed immune signatures in Lynch Syndrome patients’ blood—yet the study’s lack of sample details leaves clinicians skeptical.
IB101’s defined binding pocket marks a structural advance, but the compound has yet to enter preclinical testing.
ARPA-H’s $100 million joint-repair initiative funds three unnamed teams—only Duke confirmed—to test unproven regenerative therapies in human trials.
Flinders University’s *SLEEP* study exposes a blind spot in sleep medicine: patients with erratic night-to-night apnea patterns face 30% higher cardiovascular risk than severity scores alone predict.
Mouse studies at the German Research Center for Environmental Health reveal astrocytes—once dismissed as neuronal scaffolding—directly activate the brain’s fullness neurons via a glucose-triggered relay.
The article 'Minimal life by computer' presents a significant step forward in the development of virtual cells, with a focus on uniting AI's pattern-finding power with mechanistic models.
Microplastics have been found in every human bile sample examined in a recent study, with chronic low-dose exposure linked to mitochondrial dysfunction and senescence in cholangiocytes.
A multidisciplinary research team has identified a faster way to determine which airborne chemicals pose a threat to human lungs.
Mouse studies now show tumors disable dendritic cells by crippling their mitochondria—a vulnerability that may explain immunotherapy resistance in 30–40% of patients.
A University of Minnesota study shows fecal microbiota transplantation can reverse life-threatening inflammation in fulminant *C. difficile* within hours, slashing mortality risks.
Researchers have developed a blood test that analyzes cell-free DNA to detect multiple cancers, liver conditions, and organ abnormalities.
UCLA scientists have developed a simple and cost-effective blood test that shows promise in detecting multiple cancers, various liver conditions, and organ abnormalities simultaneously.
The ASH HematOmics Program has been developed by a team of scientists from St. Jude Children's Research Hospital, the American Society for Hematology, and the Munich Leukemia Laboratory.
The Mayo Clinic’s new protein-ranking system assigns immunogenicity scores to individual proteins, a capability absent from current transplant risk assessments.
The Salton Sea's environment affects children's lung function growth, with significant implications for public health policy.
Apple’s Studio Display XDR is now the first consumer monitor FDA-cleared for primary diagnostic imaging—a validation previously reserved for $10,000+ medical-grade screens.
The largest randomized trial of its kind found a computational method for assessing coronary blockages matched invasive testing in 92% of cases—yet regulators and clinicians aren’t ready to call it a replacement.
Spanish researchers found that people with naturally elevated dermcidin levels reported 38% fewer flu-like symptoms during peak season.
Researchers have developed an AI-powered pathology tool that can predict treatment responses for patients with extensive-stage small cell lung cancer, with a reported accuracy rate of over 80%.
A 50-patient randomized trial found no reduction in heart attack size when using Impella CP pumps in high-risk STEMI patients without cardiogenic shock.
A new text-mining method could cut bioprocess trial-and-error—but only if it survives real-world validation.
CANECPI-5, a sugarcane protein, is the key ingredient in this artificial saliva, which has shown promising results in early tests.
Researchers have identified specific biomarkers linked to digestive diseases, which can be analyzed using AI to predict various conditions.
Disrupted sleep in depressed young adults predicted insulin resistance more accurately than weight gain in a 10-year Australian study of 1,900 participants.
A single investor just turned $1 million into $385 million—without a drug, a trial, or even a double-digit headcount.
Researchers used CRISPR and epigenetic targeting to reactivate silenced tumor suppressors in AML mouse models, reducing leukemia burden.
The mutations don’t just predict epilepsy—they rewire the brain’s blueprint during the second trimester, according to Baylor’s *Neuron* paper.
Cambridge chemists turned a botched reaction into a method that uses LED light to edit drug molecules—no toxic solvents required.
Dutch surgeons just turned a 3 a.m. liver transplant into a 9 a.m. one—without harming patient outcomes.
Current antifungals fail in 40% of systemic candidiasis cases, a mortality rate driving researchers toward radical alternatives like immune metabolic reprogramming.
The Salton Sea's environment affects children's lung function growth, with significant implications for public health policy.
APOE4 carriers—roughly 1 in 4 people globally—may experience altered brain activity in their 30s, decades before Alzheimer’s symptoms emerge.
Brain scans from 34 countries reveal that air pollution and socioeconomic inequality can widen the gap between biological and chronological brain age by up to two years.
Researchers analyzing 34 countries’ exposome data pinpointed two distinct drivers of brain aging: social interactions speed cognitive decline, while pollutants erode structural integrity.
Ten patients with congenital deafness experienced improved hearing after a single injection of a new gene therapy.
GATC Health claims its AI-driven in silico multi-omics technique reduces therapeutic development costs.
Researchers have identified a small molecule that can prevent kidney stone formation in a rare genetic disorder.
Professor Jason Trubiano’s team just confirmed what clinicians suspected: **90% of hospital patients labeled ‘penicillin-allergic’ test negative** when properly evaluated.
Four types of cancer were eliminated in mice using the new drugs.
A *Nature Medicine* correction to a 2026 whole-genome sequencing study in solid cancers offers no explanation for the changes, leaving clinicians to parse its implications alone.
Swedish researchers exploited hemoproteins like hemoglobin to polymerize conductive n-PBDF directly in brain tissue, sidestepping traditional fabrication barriers.
CRISPR-based tools reactivated a silenced leukemia-suppressing gene in mice, according to JAX researchers, without editing a single DNA base pair.
Researchers at TUM have settled a six-decade dispute regarding fundamental mechanisms of visual perception in mammals.
A preprint study shows new sensors recording neural activity in brain organoids for under $500 per unit, but clinical relevance is years away.
Researchers documented zero major complications in pediatric patients undergoing SEEG-guided thermocoagulation—a rare bright spot in drug-resistant epilepsy treatment.
Epia Neuro’s neural implant doesn’t just assist stroke-damaged hands—it attempts to reprogram the brain’s motor cortex while a robotic glove forces the limb through lost movements.
STAT News analysis reveals the FDA’s ‘breakthrough’ AI devices lean toward broad-impact solutions over niche tools.
The April 2026 *Nature Medicine* editorial doesn’t just call health information important—it classifies unequal access as a *structural determinant of health*, a category previously reserved for factors like income or pollution.
Keratinocytes in the epidermis don’t just detect threats—they broadcast them via a newly identified pathway, Chinese researchers revealed in *Nature Immunology* this week.
Nearly a dozen personalized cancer vaccine platforms are now in human trials, but none have cleared regulatory approval.
Scientists at 404 Media have made a significant discovery, producing psilocybin and DMT in a tobacco plant, with potential implications for medicine and conservation.
Mayo Clinic’s five-year study reveals robotic bronchoscopy’s sub-millimeter accuracy—but clinical adoption lags behind polished demos.
Jean-Jacques Lebrun, Ph.D., led the team that made the breakthrough discovery of a protein that pancreatic cancer cells rely on to survive and grow.
UC Davis researchers’ new blood test targets a protein signature unique to *active* TB—a feature missing from every WHO-approved diagnostic currently in use.
A new text-mining method could cut bioprocess trial-and-error—but only if it survives real-world validation.
Hong Kong researchers engineered a titanium surface that obliterates *Staphylococcus aureus* biofilms in 15 minutes—using light instead of drugs.
A Phase 3 cancer vaccine trial’s undisclosed ‘narrow failure’ last August erased IO Biotech’s $127M IPO and forced a Tuesday SEC bankruptcy filing.
Antiretroviral therapy now extends near-normal lifespans in wealthy nations, yet 60% of new HIV infections still occur in sub-Saharan Africa.
ERAST’s vector database compresses 1 billion biological sequences into a searchable format—yet its paper omits the critical benchmark: how often speed comes at accuracy’s expense.
STAT News reports that a quiet effort to rename PCOS is nearing completion, with growing evidence of a male version of the condition.
A drug originally designed for erectile dysfunction now shows **unexpected muscle-strengthening effects** in children with a fatal neurological disorder.
T cells—immune system’s off-meta pick—just outplayed antibodies in a *Cell Reports* study, targeting viral ‘core files’ instead of mutable cosmetics.
A single compromised repository at CareCloud now forces 45,000+ providers to confront the same question: what patient data might be in the wrong hands?
Over 80% of variants detected in tumor sequencing fall into a gray zone—neither clearly harmful nor benign—where Hiroshima University’s new tool aims to impose order.
The study titled 'Scalable single-cell total RNA sequencing unifies coding and noncoding transcriptomics' was published in Nature Biotechnology on 31 March 2026.
Researchers are exploring a new technology that involves turning muscles into motors to treat spinal cord injuries and Crohn's disease.
Scientists at the Icahn School of Medicine at Mount Sinai have made a significant discovery about the biological processes that contribute to the development of Down syndrome.
Pericardial fat—long a suspected culprit in heart disease—now has an AI-powered measurement tool that outperforms traditional risk models by up to 20%.
A 16-week trial across 13 countries just gave pediatric cardiologists their first phase 3 data on mavacamten for obstructive HCM in youth.
T cells—immune system’s off-meta pick—just outplayed antibodies in a *Cell Reports* study, targeting viral ‘core files’ instead of mutable cosmetics.
Microsoft and Amazon’s new AI health tools process patient data at scale—but neither has cleared FDA validation for clinical use.
Twenty thousand lab-grown human retinas—each a cluster of cells no wider than a sesame seed—just rewrote a key chapter in how cone photoreceptors resist degeneration.
Sweden’s Karolinska University Hospital has sequenced over 15,000 genomes for rare diseases, diagnosing 23%—a figure that underscores both progress and persistent gaps.
Rare mutations in *CHD8* and *SCN2A*—genes long tied to autism in European populations—now appear equally significant in Latin American cohorts, per a 10,000-person study.
Nature Medicine published a study on making infectious disease data local and accessible, with a DOI of 10.1038/s41591-026-04328-3.
Insilico Medicine’s AI platform has never produced an FDA-approved drug—but Eli Lilly just wagered up to $2.75 billion on its potential.
Rare mutations in *CHD8* and *SCN2A*—genes long tied to autism in European populations—now appear equally significant in Latin American cohorts, per a 10,000-person study.
A 12-patient trial saw zero relapses and low severe GVHD rates with VIC-1911, but the lack of a control group leaves key questions unanswered.
A team led by neuroscientists at the University of Pennsylvania has compiled the most detailed map yet of brain connectivity across nine decades of life.
A 2023 *Nature Aging* study analyzing sleep EEGs from 10,000+ adults found subtle brainwave patterns that correlated with accelerated biological aging and future dementia risk.
A study of 523 stroke survivors reveals the brain’s undamaged side may temporarily ‘de-age’ to compensate for injury—but the implications for recovery remain unclear.
Dr. James White, MD, found a clear benefit to using the 4D model to target treatment for CRT patients.
Hummingbirds consume alcohol levels equivalent to several human drinks daily—yet show zero signs of impairment.
The FDA’s involvement marks Whoop’s first serious attempt to shift from luxury fitness tracker to medical device.
Over 50% of women with disabilities prefer self-collected HPV tests, per a Journal of Medical Screening study.
CVS faces a settlement over manipulated insulin prices, potentially saving Americans $7 billion.
Gotistobart increased survival in PRESERVE-003 for metastatic squamous NSCLC patients resistant to immunochemotherapy.
A 1,700-patient study at the 2024 ESMO Congress found ctDNA detected relapse in triple-negative breast cancer with 85% accuracy.
The hunt for Parkinson’s disease mechanisms just got a new lead: a cellular ‘overflow valve’ that, when broken, may let toxins accumulate.
Optogenetic mapping in 24 mice revealed a neural feedback loop between the amygdala and prefrontal cortex that adjusts fear responses in real time.
The hippocampus and entorhinal cortex—Alzheimer’s favorite targets—now have genetic aging blueprints, thanks to deep learning crunching GWAS data.
New research in *Genetic Engineering & Biotechnology News* reveals how epigenetic alterations from gut inflammation endure long after healing, potentially setting the stage for colon cancer.
Telmisartan, an FDA-approved blood pressure drug, has been found to enhance the cancer-killing activity of olaparib, according to a study led by Tyler J. Curiel, MD, MPH, FACP.
When parasitic worms invade the gut, the body’s response goes beyond local inflammation.
Vitamin B3 neutralizes microRNA-93, a genetic driver of fatty liver disease.
Current heart failure diagnostics rely on invasive catheters or radiation—yet a Oxford-led team just mapped cardiac oxygen use in three minutes using standard MRI machines.
Denali's Surnazyme treats Hunter syndrome in under 2,000 global patients.
Xaira's X-Cell model is the largest virtual cell model to-date, with 1 million parameters, according to the company's press release.
IB101’s defined binding pocket marks a structural advance, but the compound has yet to enter preclinical testing.
Researchers from UIC have made a significant breakthrough in the treatment of drug-resistant herpes, using an FDA-approved cancer drug, doxorubicin, to target the virus.
Neuroscientists have now measured dopamine’s influence on brain activity in intervals as brief as 100 milliseconds—faster than a human blink.
New blueprint aims to accelerate approvals for rare pediatric gene therapies.
In vivo CAR-T trials show promise, skipping lab processing.
Hummingbirds consume alcohol levels equivalent to several human drinks daily—yet show zero signs of impairment.
A Nature Metabolism study reveals metformin activates the AMPK pathway via the PEN2 protein.
Scientists identify 95% fatality rate for small cell lung cancer patients.
MSKCC's in vivo CAR-T trial shows promise for 5 myeloma patients.
A recent study suggests the brain’s overreaction to minor disturbances may contribute to falls in older adults and Parkinson’s patients.
Tirzepatide + hormone therapy yields 35% more weight loss for women over 50.
CVS faces a settlement over manipulated insulin prices, potentially saving Americans $7 billion.
The 'falls after stroke trial' study found a 33% reduction in falls among stroke survivors over 12 months, according to the British Medical Journal.
Dr. James White, MD, found a clear benefit to using the 4D model to target treatment for CRT patients.
Researchers at MIT modified lipid nanoparticles with aromatic compounds.
South Korean materials scientists designed the powder’s particles to resonate at 300 Hz—matching the average electric toothbrush’s vibration frequency—according to the *Journal of Dental Research*.
Researchers documented zero major complications in pediatric patients undergoing SEEG-guided thermocoagulation—a rare bright spot in drug-resistant epilepsy treatment.
IB101’s defined binding pocket marks a structural advance, but the compound has yet to enter preclinical testing.
BIIB094’s phase 1 trial marks the first time an antisense oligonucleotide has successfully targeted LRRK2 in Parkinson’s patients.
The LungIMPACT trial involved over 15,000 participants and found no significant reduction in time to diagnosis with AI-based prioritization.
Researchers have developed stitches that release anti-inflammatory drugs for weeks, but the technology is years from clinical use.
For the 537 million adults living with diabetes worldwide, the ritual of daily insulin injections is a reminder of medicine’s stubborn limits.
The ethical and scientific quagmire of animal testing may have a new contender: genetically engineered, brainless organ systems.
Scientists at Columbia's Zuckerman Institute and the University of Texas at Dallas conducted a study to shed light on how the human brain ages.
Australia's Centre for Cancer Biology exposed CD47 as glioblastoma's growth engine, not just an immune shield, yet clinical translation stays distant.
A Swedish study reveals an approved drug can revive immune cells exhausted by HIV—but only in lab dishes, not patients.
For decades, the dream of scarless wound healing has hovered just beyond reach—until now.
Keratinocytes in the epidermis don’t just detect threats—they broadcast them via a newly identified pathway, Chinese researchers revealed in *Nature Immunology* this week.
mRNA cancer vaccines show promise but face years of trials—progress isn’t the same as proven therapy.
New blood test detects 90% of early-stage pancreatic cancer cases with four-marker panel.
Deactivating a brainstem region tied to coughing/laughing in rodents normalized blood pressure—hinting at hypertension’s overlooked neural switch.
Apogee's eczema drug matches Dupixent's relief with fewer injections.
Novartis drops $3B on SNV4818, a PI3Kα inhibitor claiming pan-mutant coverage—where alpelisib’s toxicity and modest efficacy leave room for a rival.
Childhood trauma scars the brain—but 150+ minutes of weekly exercise may rewire its stress circuits, study finds.
Neuroscientists identify synchronized neuron clusters—engrams—as the likely physical basis of memory, but evidence remains observational and limited to anima...
Roche’s breast cancer pill persevERA flunks crucial Phase 3 trial, costing the pharma giant its blockbuster hopes worth billions.
mRNA cancer vaccines show promise but face years of trials—progress isn’t the same as proven therapy.
Texas A&M researchers found FGFR1 boosts cholesterol uptake in prostate cancer cells, fueling tumor growth and therapy resistance.
Blood test for NfL protein predicts post-cardiac-arrest cognitive decline with 84% accuracy in ESC 2026 study.
AI debunks decades of neuroscience dogma: London cabbies’ legendary nav skills don’t come from distinctive brain anatomy.
*E. coli* Nissle, a gut-friendly probiotic, now doubles as a tumor-infiltrating drug manufacturer in lab mice.
153 studies spanning 20 years link early screen time to doubled mental health risks in teens.
A study in *GEN News* identifies tunneling nanotubes as a key pathway for mutant huntingtin protein transfer in brain cells.
Rare patients who continue to suppress HIV after treatment offer an important clue, but they do not yet offer a new care standard.
A single amino-acid change in an experimental T cell receptor improved prostate tumor killing in mouse models.
Researchers have developed TLPath, a machine learning system that infers telomere length from standard H&E-stained histopathology slides — a key indicator of cellular aging and health risks.
A recent study published in Nature Medicine has found that a deep learning model using smartwatch data can predict peak oxygen uptake and unplanned healthcare events in patients with heart failure.
Boston University team finds dopamine signal in mice that encodes movement direction—rewriting how we link vision to action.
A *Nature Biotechnology* review published this March outlines the first coherent vision for AI that could unify genomics, protein folding, and synthetic biology under one model.
A new study suggests metastatic cells can push healthy lung cells to produce lipids that support tumor growth.
Human biomarker study flags overactive brain circuits as a schizophrenia drug target—but clinical use remains a decade away.
AI-designed antibody fragments, small enough to be produced inside human cells, have shown potential to neutralize proteins tied to Alzheimer’s and MND—though only in lab models so far.
Swedish researchers have translated nerve signals into leg movement commands, including toe wiggling, in a first for above-knee amputees.
A Boston surgical team rehearsed a high-risk pediatric procedure on a digital twin of the patient’s heart before making the first incision.
Lab-grown CAR T cells bypass external editing—preclinical success against 3 cancers, a major leap for solid tumors.
East Asian men with a missing Y chromosome in their pancreatic cells face 30% higher diabetes odds—*but only if their genetic risk is otherwise low*, per a *Nature Medicine* analysis of 200,000+ genomes.
Xaira Therapeutics has launched X-Cell, an AI model for virtual cell simulation, accompanied by a 57-page technical paper.
In 2019, Georg Schett at Friedrich-Alexander University Erlangen-Nürnberg achieved durable remission in a systemic lupus erythematosus patient using CAR-T therapy — a result that launched a global research expansion beyond oncology.
Austrian team’s sIgA-purifying resin cuts mucosal therapy costs—if stability hurdles clear in trials.
A new study published in Nature Biotechnology has developed a generative modeling framework that enables petascale synthesis of designed DNA, with a DOI of 10.1038/s41587-026-03020-8.
Lecanemab, a key Alzheimer's drug, has been found to activate immune cells through the Fc fragment of the antibody, according to researchers.
A breakthrough noninvasive method measures beta cell mass in living patients—potentially rewriting type 1 diabetes treatment strategies.
Researchers published findings on April 17 detailing how ML models analyze atopic dermatitis to forecast respiratory illness.
New method measures cancer’s hidden gene-splicing toolkit, proving tumors weaponize RNA editing to fuel growth and survival.
Lecanemab, a key Alzheimer's drug, has been found to activate immune cells through the Fc fragment of the antibody, according to researchers.
New method measures cancer’s hidden gene-splicing toolkit, proving tumors weaponize RNA editing to fuel growth and survival.
Human blood now carries 420ppm CO₂—higher than ever in history—and doctors don’t know what it does to our health.
A new wearable device designed to measure flatulence has produced an unexpected preliminary finding: humans may pass gas significantly more often than previously believed.
Cambridge chemists turned a botched reaction into a method that uses LED light to edit drug molecules—no toxic solvents required.
A new amino acid formulation appears to improve LNP uptake in cells, though no human data yet exists.
A new study published in Nature Medicine has provided some of the most comprehensive evidence yet that oral antibiotics can permanently alter the composition of the gut microbiome.
A semaglutide-bimagrumab combo in phase 2 preserved nearly all lean mass while cutting fat dramatically.
Ipsen's decision to pull Tazverik affects thousands of patients worldwide.
Stanford’s engineered CAR-astrocytes cut amyloid-beta plaques by 40–60% in Alzheimer’s-prone mice, but only when given before pathology began.
A father and daughter with no lifestyle risk factors led Mayo Clinic to uncover a rare genetic cause of fatty liver disease.
A Bronze Age sheep from Russia’s Ural Mountains is the first non-human host ever found carrying the ancient plague bacterium *Yersinia pestis*.
LRG1, a protein previously linked to blood vessel formation, now stands accused of starving retinal cells in diabetic mice by constricting their microvasculature.
Two genes, *Tcf7* and *Lef1*, act as master regulators of T cell exhaustion, according to a *Nature Immunology* study combining CRISPR screens with 60,000-cell sequencing.
The AI model, trained on genome-wide DNA fragmentation data, distinguished early fibrosis from healthy controls with 85% accuracy in preliminary tests—no mutations required.
Former ARPA-H data chief Shannon Sartin is pushing a policy to turn patient health data into a regulated utility, potentially upending its current corporate ownership.
Obesity treatment may have just taken a measured step forward.
East Asian men with a missing Y chromosome in their pancreatic cells face 30% higher diabetes odds—*but only if their genetic risk is otherwise low*, per a *Nature Medicine* analysis of 200,000+ genomes.
